硫辛酸
庆大霉素
粘附
伤口愈合
抗菌活性
材料科学
再生(生物学)
抗生素
化学
医学
细菌
生物化学
外科
细胞生物学
有机化学
生物
抗氧化剂
硫辛酸
遗传学
作者
Yamei Gao,Xiang Zhan,Shaohu Huo,Ling Fu,Zhi Tang,K. H. Qi,Chunchun Lv,Chengyuan Liu,Zhao Yu,Shenggang Ding,Yongmei Lv
摘要
Bacterial infections remain a major concern during wound healing and tissue bonding. The excessive proliferation of bacteria will seriously hinder the repair of the wound and even lead to death. Generally, surgical sutures might cause damage to the surrounding tissues and inevitable infection due to the unfixed shape of the wound. Thus, it is urgent to develop novel antibacterial skin dressing with self-healing and strong adhesion properties. Herein, we prepared an antibacterial and self-healable hydrogel with strong adhesion activity through natural small molecules, including thioctic acid TA and gentamicin (GM). The rapid ring-opening-polymerization of the TA (PTA) forms the backbone of macromolecules, and the functional hydrogel was constructed with the crosslinking of GM, termed as G-PTA, which offers hydrogen bonding interactions between the amino and hydroxyl groups of GM and carboxylic group side chains of poly(TA). The synthesized hydrogel exhibited rapid self-healing ability and strong tissue adhesion due to the internal dynamic disulfide bonds and multiple hydrogen bonds. Importantly, the introduction of GM enabled the G-PTA hydrogel to sustainably release antibiotics and exhibit a durative antibacterial effect with the degradation of PTA, which further shorten the therapeutic time and enhance tissue regeneration in a wound infection model. The in vitro and in vivo experiments demonstrate that the G-PTA hydrogel has potential as a surgical antibacterial biological adhesive, especially for bacterial wound infections.
科研通智能强力驱动
Strongly Powered by AbleSci AI