免疫染色
单克隆抗体
老年斑
细胞粘附分子
病理
小胶质细胞
生物
阿尔茨海默病
淋巴细胞功能相关抗原1
细胞间粘附分子-1
免疫组织化学
神经细胞粘附分子
抗体
免疫学
细胞粘附
医学
疾病
细胞
生物化学
炎症
作者
J. M. Rozemuller,Piet Eikelenboom,Steven T. Pals,Frank Stam
标识
DOI:10.1016/0304-3940(89)90547-8
摘要
Immunostaining for glycoproteins of the LFA-1 family (leucocyte function-associated antigens) was demonstrated on cells in the corona around senile plaques in Alzheimer's disease (AD) and in small glial cells in the subcortex of patients with AD and controls. These cells, which are usually referred to as microglial cells, showed positive immunohistochemical staining with monoclonal antibodies directed against the α-chains of all 3 LFA-1 family members, i.e. LFA-1, iC3b-receptor and P150,95, as well as with a monoclonal antibody against the common β-chain. In the corona a diffuse staining for a ligand of LFA-1, intercellular adhesion molecule (ICAM)-1, was found as well. It is suggested that these molecules of the LFA-1 family may have a function in the dynamics of neuritic degeneration and sprouting.
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