激进的
化学
表面改性
功能群
苯
分子
组合化学
光化学
计算化学
有机化学
聚合物
物理化学
作者
Yao Chen,Mengxia Lv,Yuxin Zhang,Yao Wu,Linkun Ying,Jielin Tang,Xiangnan Gong,Jianmin Zhang,Zengqiang Song
标识
DOI:10.1021/acs.joc.2c01567
摘要
A new, simple, and metal-free route for the diselenation of maleimides has been first developed employing (bis(trifluoroacetoxy)iodo)benzene (PIFA) at room temperature. The present method is compatible with different functional groups, and various diselenyl maleimides were obtained in moderate to excellent yields. Moreover, this protocol further highlights the unique practical application for the functionalization of biologically relevant molecules and amino acid derivatives. Preliminary mechanism studies suggest that radicals may be involved in this novel transformation. Additionally, this protocol is also applicable for the monoselenation of maleimides by switching the reaction conditions and selenation of other electron-deficient alkenes.
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