三阴性乳腺癌
乳腺癌
癌症研究
生物
转移
上皮-间质转换
自噬
甘露糖受体
癌症
受体
免疫学
细胞凋亡
生物化学
遗传学
巨噬细胞
体外
作者
Hong Zhang,Tao Zhu,Wenchun Xu,Bichen Liu,Kaifeng Wu,Yibing Yin,Xuemei Zhang
标识
DOI:10.1080/21505594.2023.2283898
摘要
The detoxified pneumolysin derivative ΔA146Ply has been proven to have a direct anti-triple negative breast cancer effect by our group, but its work model remains unclear. In this study, we focused on its ability to inhibit triple-negative breast cancer metastasis. We found that ΔA146Ply suppressed the migration and invasion of triple-negative breast cancer cells by activating mannose receptor and toll-like receptor 4. Their activation triggers the activation of the mammalian target of rapamycin signaling, sequentially leading to autophagy, transforming growth factor-β1, and epithelial-mesenchymal transition inhibition. Furthermore, the combination of doxorubicin and ΔA146Ply significantly inhibited triple-negative breast cancer progression and prolonged survival in tumor-bearing mice. Taken together, our study provides an alternative microbiome-based mannose receptor-targeted therapy for triple-negative breast cancer and a novel theoretical and experimental basis for the downstream signaling pathway of the mannose receptor.
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