结晶
分辨率(逻辑)
溶剂
组合化学
手性拆分
吞吐量
化学
对映体过量
手性衍生剂
有机化学
对映体
手性柱色谱法
对映选择合成
计算机科学
催化作用
人工智能
电信
无线
作者
Jun Qiu,Jason M. Stevens
标识
DOI:10.1021/acs.oprd.0c00348
摘要
Using a statistical Z-score methodology, enantiomeric excess (ee) data from our historical high-throughput classical chiral resolution screens were analyzed. In total, 19 of the screens used chiral acids as resolving agents, and 20 used chiral bases. The results show clear trends in terms of the selection of chiral acids/bases in conjunction with a crystallization solvent. We rank ordered resolving agents, solvents, and resolving agent/solvent combinations by applying the Z-score method on the ee of isolated solids, and provided recommendations on executing more efficient classical chiral resolution screening for synthetic intermediates.
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