海马旁回
失调家庭
前额叶皮质
心理学
神经科学
额下回
功能磁共振成像
额中回
额上回
创伤后应激
海马体
临床心理学
颞叶
认知
癫痫
作者
Trevor Steward,Pritha Das,Gin S Malhi,Richard A. Bryant,Kim L. Felmingham
标识
DOI:10.1016/j.euroneuro.2020.09.634
摘要
The current study aimed to identify alterations in brain activation and connectivity related to memory suppression in posttraumatic stress disorder (PTSD) using the Think/No-Think paradigm during functional magnetic resonance imaging (fMRI). Reduced activation in the parahippocampal cortex during No-Think vs. Baseline trials was found in participants with PTSD compared to controls with no history of trauma (pFWE<0.05). Trauma-related intrusive memories (r = 0.562, p = 0.046) and avoidance behaviors (r = 0.636, p = 0.020) were positively correlated with parahippocampal cortex activation during memory suppression in the PTSD group. Psychophysiological interactions (PPI) analysis identified increased functional connectivity between the inferior frontal gyrus and the parahippocampus during memory suppression in the PTSD group compared to trauma-free controls (pFWE<0.05). Our findings support a network-based phenotype for altered memory suppression in individuals with PTSD rooted in dysfunctional parahippocampal-prefrontal coupling. These data validate neural models of PTSD and offer a novel neural circuit for brain-based interventions targeting trauma-related memory.
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