阿魏酸
体内
抗血栓
化学
血小板
药理学
体外
生物化学
凝血酶
血小板活化
细胞毒性
免疫学
医学
内科学
生物
生物技术
作者
Jong-In Choi,Jong Kook Park,Ki-Man Kim,Hyo‐Jeong Lee,Seung Kim
摘要
Abstract We discovered recently in vitro and in vivo antithrombotic and cytotoxicity effects of ferulic acid. The cytotoxicity assays showed that ferulic acid (∼300 μg/mL) did not cause any significant toxicity on three cell lines, platelets, leukocytes, and erythrocytes. In vitro assays showed inhibitory effects of ferulic acid on thrombin (THR)‐ or collagen/epinephrine‐stimulated platelet activation by inhibiting platelet aggregation, and decreasing clot retraction activity. The in vitro effect of ferulic acid on THR‐stimulated platelet activation was proved by the decrease in the secretion of serotonin from the platelets. The anticoagulant effects of ferulic acid were confirmed by the prolongation of the intrinsic or/and extrinsic pathways and the delay of recalcification time in plasma coagulation. Ferulic acid had antithrombotic effect in acute thromboembolism model in vivo , and decreased the expression of α IIb β 3 /FIB and phosphorylation of AKT in THR‐stimulated platelet activation in vivo , and their antithrombotic efficacies hold promise for therapeutic targeting in our ongoing studies.
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