Immunology of Endometriosis; a Systematic Review

Background Endometriosis is a common and gynecologic illness affecting women in reproductive age and characterized by the growth of endometrial-like tissue and stroma outside the uterine cavity.It is also a significant cause of infertility.The cause of endometeriosis is still unclear but an increasing number of studies have been investigated the role of immune system in its etiology and pathogenesis.So, it is well known that endometriosis is an inflammatory disease and has dysfunction in patient's immune response.The development of endometriosis may be influenced by immune factors including formation of autoantibodies, impaired immune recognition and clearance of ectopic endometrial cells.In this review, we will summarize the current knowledge about immunological factors in women with endometriosis that provide the basis for developing new approaches to patient management.In this review, the basic contents were obtained from textbooks and new surveies were searched from pubmed, science direct and google scholar in the period of 1980-2015.Conclusion Immunological factors have been considered as important factors in the prevention and treatment of endometriosis.In addition, clinical studies are recommended to understanding the mechanism and the role of immunological factors in the prevention and treatment of endometriosis.