Expression and distribution of NGF、P75NTR、TrkA in colon enteric nervous system of human embryos

Objective To observe the expression and distribution of nerve growth factor (NGF),P75NTR and TrkA in colon enteric nervous system(ENS)of human embryos and their relationships with the development of colon ENS in human embryos.Method The neurons in colon ENS was shown by using NGF,P75NTR and TrkA as first antibodies in immunohistochemistry.Result With its development,the expression level of P75NTR descend continuously in colon ENS of human embryos,but the expression level of the NGF and the TrkA rose continuously,the ratios of the P75NTR and the NGF or TrkA are changing continuously.Conclusion The NGF,TrkA,P75NTR participates the development of the colon nervous enteric system.