谷氨酰胺
嘧啶代谢
生物
氨基酸
新陈代谢
精氨酸
天冬酰胺
重编程
氨基酸合成
生物化学
代谢途径
癌细胞
丝氨酸
癌症
细胞
赖氨酸
遗传学
酶
嘌呤
作者
Na Liu,Feng Shi,Lifang Yang,Weihua Liao,Yang Cao
标识
DOI:10.1016/j.bbcan.2022.188724
摘要
Viruses lack essential living system, so they must hijack host cell metabolism for its survival and reproduction. Interestingly, the metabolic reprogramming induced by oncovirus is critical for the malignant transformation. Amino acid can supply the source of nitrogen and carbon for biosynthesis or fulfill the energy requirement for the rapid growth of tumor cells. Amino acid metabolism caused by oncogenic viral infection often mirrors metabolic changes observed in cancer cells, such as glutamine addiction, asparagine dependence, arginine auxotrophy and active serine/ proline metabolism. In this review, we describe amino acid metabolism reprogramming in tumors. We also discuss how oncogenic viruses hijack amino acid metabolism in the stress status. Further research on the metabolic profile of virus-related cancers will not only provide new targets for tumor prevention and treatment, but novel diagnostic and therapeutic strategies as well.
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