坏死性小肠结肠炎
医学
缺氧(环境)
重症监护医学
疾病
发病机制
流行病学
小肠结肠炎
儿科
生物信息学
病理
生物
化学
有机化学
氧气
作者
Jonathan A. Berken,Jill Chang
出处
期刊:Developmental Neuroscience
[S. Karger AG]
日期:2022-01-01
卷期号:44 (4-5): 295-308
被引量:14
摘要
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of the premature infant with high mortality and morbidity. Children who survive NEC have been shown to demonstrate neurodevelopmental delay, with significantly worse outcomes than from prematurity alone. The pathways leading to NEC-associated neurological impairments remain unclear, limiting the development of preventative and protective strategies. This review aims to summarize the existing clinical and experimental studies related to NEC-associated brain injury. We describe the current epidemiology of NEC, reported long-term neurodevelopmental outcomes among survivors, and proposed pathogenesis of brain injury in NEC. Highlighted are the potential connections between hypoxia-ischemia, nutrition, infection, gut inflammation, and the developing brain in NEC.
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