Insights into the Molecular Basis of Kallman Syndrome

Abstract Kallmann syndrome (KS) consists of anosmia related to defective olfactory bulb development and hypogonadotrophic hypogonadism due to gonadotrophin‐releasing hormone (GnRH) deficiency. Two genes have been identified so far: KAL‐1 , encoding anosmin‐1, and KAL‐2 ,encoding fibroblast growth factor receptor 1 (FGFR1).