连续流动
串联
衍生工具(金融)
氯化物
组合化学
化学
可扩展性
弗里德尔-克拉夫茨反应
产品(数学)
吞吐量
计算机科学
有机化学
材料科学
数学
催化作用
生化工程
数据库
工程类
电信
几何学
金融经济学
经济
复合材料
无线
作者
Chao Shan,Ranran Li,Xinchao Wang
出处
期刊:RSC Advances
[The Royal Society of Chemistry]
日期:2024-01-01
卷期号:14 (4): 2673-2677
摘要
A β-naphthol library has been efficiently constructed utilizing a mild continuous flow procedure, relying on a tandem Friedel-Crafts reaction and starting from readily available arylacetyl chloride and alkynes. Multiple functionalized β-naphthols can be acquired within 160 s in generally high yields (up to 83%). Using an electron-rich phenylacetyl chloride derivative (4-OH- or 4-MeO-) provides spirofused triene dione as the primary product. A scale-up preparation affords a throughput of 4.70 g h-1, indicating potential large-scale application. Herein, we present a rapid, reliable, and scalable method to obtain various β-naphthols in the compound library.
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