催汗剂
周围神经病变
医学
外围设备
糖尿病神经病变
腓肠神经
神经纤维
皮肤电导
糖尿病
汗水
内科学
生物医学工程
外科
内分泌学
解剖
作者
Christian Tronstad,Oliver Pabst,Maryam Amini,Inge Petter Kleggetveit,Ole Elvebakk,Ørjan Grøttem Martinsen,Trond Jenssen,Jonny Hisdal,Tore Julsrud Berg,Elisabeth Qvigstad
标识
DOI:10.1109/embc48229.2022.9871101
摘要
Diabetic peripheral neuropathy (DPN) affects a large proportion of people with diabetes, and early detection is essential to prevent further progression. Widespread clinical testing relies on simplicity and cost-effectiveness of examination. Early signs of DPN may be detected by assessing the sudomotor nerves, and sudomotor activity can be measured by bioimpedance. We present a prototype toe probe for DPN detection including sensors for measuring skin AC conductance, skin temperature and humidity. The prototype was tested on five participants with DPN and five healthy age-matched controls in a pilot study. Sudomotor sensor responses to a simple deep breathing test were very weak or absent in the DPN group, with all controls having larger responses than the DPN group. Evaporation was lower for the DPN group, and skin temperature was higher on average. For the same foot, the results for sudomotor responses were in agreement with sensory neurography amplitudes from the sural nerve whereas the monofilament test gave normal results for two of the DPN participants. If sufficient detection accuracy is confirmed in larger studies, the method may provide a simple and cost-effective tool to support clinical examination. Clinical Relevance— We present the early realization and testing of a simple device to support early detection of diabetic peripheral neuropathy.
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