化学
吗啉
乙酰丙酮
吡唑
抗菌剂
联氨(抗抑郁剂)
三嗪
胺气处理
单晶
抗真菌
三聚氯氰
药物化学
组合化学
有机化学
结晶学
医学
色谱法
皮肤病科
作者
Anamika Sharma,Hazem A. Ghabbour,Shams Tabrez Khan,Beatriz G. de la Torre,Fernando Alberício,Ayman El‐Faham
标识
DOI:10.1016/j.molstruc.2017.05.040
摘要
A new series of pyrazole-containing s-triazine derivatives were synthesized by reaction of the corresponding s-triazinyl hydrazine derivatives with acetylacetone in the presence of HClO4 or DMF/TEA. The former method allowed the preparation of the target products with higher yields. All compounds were fully characterized. X-ray single crystal diffraction for two representative compounds (4-(4,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazin-2-yl)morpholine and N-benzyl-4-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)-1,3,5-triazin-2-amine) was studied and the molecular structures were optimized using the DFT/B3LYP method. The structures were found to be in agreement with X-ray structures. The antimicrobial and antifungal activity of the prepared compounds were tested against the growth of several microorganisms.
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