Synthesis, Characterization and Antibacterial Activity of Chitosan/TiO<sub>2</sub> Microspheres

In this study, chitosan (CS)/titanium dioxide (TiO 2 ) microspheres with different nanoTiO 2 content were obtained by suspension cross-linking technique and characterized by FT-IR and SEM. The strong peak of C=N stretching vibrations at 1641 cm -1 were found which demonstrated that amino groups of CS reacted with aldehyde group of glutaraldehyde. SEM photographs showed that the CS/TiO 2 microspheres were spherical, and the size of the CS/TiO 2 microspheres ranging from 50 to 170 μm was analyzed with the software of Image J. The entrapment efficiency of the CS/TiO 2 microspheres was up to 67.7%. Compared with CS, CS/TiO 2 microspheres had better antibacterial activity against S. aureus and E. coli with a MIC value of 0.0125%.