Objective: Our aim was to observe the effect of somatostatin on treatment of severe acute pancreatitis. Methods: We divided 102 cases of severe acute pancreatitis into somatostatin treating group (n=52) and control group (n= 50). Contrast analysis was made between the two groups on the mortality, death reason, and hospital stay of pancreatic cyst, pancreatic abscess, pancreatic fistula, bowel fistula, intraabdominal hemorrhage. Results: The complication rate of somatostatin treating group was obviously less than that of control group. Somatostatin could decrease the mortality of severe acute pancreatitis, shorten the hospital stay and the treating time. Somatostatin had important influence in the treatment of severe acute pancreatitis. Conclusion: Somatostatin has important value for the treatment of severe acute pancreatitis. The earlier we performance of the treatment, the better effect we would have.