糖尿病
疾病
肠道菌群
病因学
医学
免疫学
微生物群
基因组
发病机制
生理学
生物
生物信息学
内科学
内分泌学
生物化学
基因
作者
Ganesan Velmurugan,Vasudevan Dinakaran,Jeyaprakash Rajendhran,Krishnan Swaminathan
标识
DOI:10.1016/j.tem.2020.01.013
摘要
Diabetes and cardiovascular disease (CVD) have evolved as the leading cause of mortality and morbidity worldwide. In addition to traditional risk factors, recent studies have established that the human microbiota, particularly gut bacteria, plays a role in the development of diabetes and CVD. Although the presence of microbes in blood has been known for centuries, mounting evidence in this metagenomic era provides new insights into the role of the blood microbiota in the pathogenesis of non-infectious diseases such as diabetes and CVD. We highlight the origin and physiology of the blood microbiota and circulating microbial metabolites in relation to the etiology and progression of diabetes and CVD. We also discuss translational perspectives targeting the blood microbiota in the diagnosis and treatment of diabetes and CVD.
科研通智能强力驱动
Strongly Powered by AbleSci AI