西妥昔单抗
医学
结直肠癌
肿瘤科
内科学
突变
V600E型
癌症研究
癌症
业务
遗传学
生物
基因
作者
Scott Kopetz,Axel Grothey,Rona Yaeger,Eric Van Cutsem,Jayesh Desai,Takayuki Yoshino,Harpreet Wasan,Fortunato Ciardiello,Fotios Loupakis,Yong Sang Hong,Neeltje Steeghs,Tormod K. Guren,Hendrik‐Tobias Arkenau,Pilar García‐Alfonso,Per Pfeiffer,Sergey Orlov,Sara Lonardi,Elena Élez,Tae-Won Kim,Jan H.M. Schellens
标识
DOI：10.1056/nejmoa1908075
摘要
Patients with metastatic colorectal cancer with the BRAF V600E mutation have a poor prognosis, with a median overall survival of 4 to 6 months after failure of initial therapy. Inhibition of BRAF alone has limited activity because of pathway reactivation through epidermal growth factor receptor signaling.
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