Progress of determination method and standardization of estrogenin serum

Estrogen in human serum plays the irreplaceable roles in pregnancy. It can establish and maintain female secondary sexual characteristics in a low concentration. Determination of estrogen concentrations is an effective means to understand the female endocrine function and diagnose diseases associated with endocrine disorders clinically. With the development of analysis techniques, various types of estrogen determination methods in medical laboratory are established from radioimmunoassay and enzyme immunoassay to enzyme immunoassay and gas or liquid chromatography/mass spectrometry. These technologies play vital roles in estrogen detection, related disease monitoring and prognosis. Key words: Estrogen; Standardization