光热治疗
吲哚青绿
生物医学工程
材料科学
光热效应
荧光
纳米技术
介孔二氧化硅
生物物理学
化学
介孔材料
病理
光学
医学
催化作用
物理
生物
生物化学
作者
Huiquan Wang,Pengfei Hu,Yu Zheng,Zhe Zhao,Bin Zheng,Hanjie Wang
标识
DOI:10.1016/j.msec.2017.05.131
摘要
Photothermal therapy (PTT) has drawn tremendous attention because of its high therapeutic efficiency in targeting cells while minimizing the damage to normal tissues and organs. Tungsten oxide (W18O49, WO) plays a pivotal role in PTT development and its use in PTT systems has been extensively studied. However, it is difficult to control morphology of WO through conventional hydrothermal method. Which make its related researches have been limited up to now. In this study, we describe the construction and effects on tumor of a novel nanoplatform based on WO and indocyanine green (ICG) loaded in mesoporous silica nanoparticles (MSN) for dual-modal PTT and near-infrared imaging. (WO+ICG)@MSN could efficiently control WO shape without the need of surface modification due to its water-soluble of MSN. (WO+ICG)@MSN produced a PTT synergistic effect under irradiation of a single 808nm near-infrared (NIR) laser. Notably, an enhanced lethal effect of the 808nm laser triggering dual-modal therapy on B16 tumor cells was observed. The in vivo animal experiments showed that (WO+ICG)@MSN induced an effective solid tumor reduction under 808nm NIR light irradiation, revealing the potential of these nanocomposites as a NIR-mediated dual-modal therapeutic platform for cancer treatment.
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