铋
GPX4
活性氧
谷胱甘肽
化学
光热治疗
氧化应激
纳米技术
材料科学
谷胱甘肽过氧化物酶
生物化学
酶
有机化学
作者
Guo-Bo Chen,Lin Gu,Yongtian Liu,Jun Du,Qingwen Qi,Qi Miao,Mingjun Xu,Yuqing Miao,Yuhao Li
标识
DOI:10.1016/j.jcis.2023.11.119
摘要
Ferroptosis-mediated tumor treatment is constrained by the absence of single-component, activatable multifunctional inducers. Given this, a topological synthesis strategy is employed to develop an efficient bismuth-based semiconductor nano-photocatalyst (Bi2O3:S) for tumor ferroptosis therapy. Photo-excited electrons can participate in the reduction reaction to produce harmful reactive oxygen species (ROS) when exposed to near-infrared light. Meanwhile, photo-excited holes can contribute to the oxidation reaction to utilize extra glutathione (GSH) in tumors. In the acidic tumor microenvironment, bismuth ions generated from Bi2O3:S may further cooperate with GSH to amplify oxidative stress damage and achieve biodegradation. Both promote ferroptosis by downregulating glutathione peroxidase 4 (GPX4) expression. Besides, sulfur doping optimizes its near-infrared light-induced photothermal conversion efficiency, benefiting its therapeutic effect. Thus, bismuth ions and holes synergistically drive photo-activable ferroptosis in this nanoplatform, opening up new avenues for tumor therapy.
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