Infrared Small Target Detection faces challenges due to limited global perception and feature ambiguity in complex scenarios. To address these issues, we propose a novel Multi-Scale Channel Attention and Cross-Layer Fusion Network (MACFNet). The framework integrates three key innovations: (1) The Feature Convolution Attention Transformer (FCAT) addresses limited global perception by combining local features and global contexts to enhance target representation; (2) The Efficient Channel and Spatial Attention (ECSA) module resolves feature ambiguity by optimizing discriminative feature weighting; (3) An enhanced M-UNet architecture incorporates Channel-wise Cross Fusion Transformer (CCT) modules to enable effective cross-scale semantic alignment. Extensive experiments on the SIRST and NUDT-SIRST datasets demonstrate state-of-the-art performance, achieving significantly higher IoU of 0.8396 and 0.9346, respectively, surpassing existing model-driven and data-driven methods while maintaining a real-time capable inference speed of 29.7167 FPS.