原肌球蛋白受体激酶B
七氟醚
前额叶皮质
抗抑郁药
脑源性神经营养因子
海马体
行为绝望测验
开阔地
神经营养因子
医学
伏隔核
药理学
神经科学
内科学
心理学
受体
认知
作者
Shuzhen You,Yishuang Wu,Yongxin Guo,Meng Wu,Mingzi Ran,Fang Cao,Xinyu Hao,Yang Lv,Hong Zhang,Weidong Mi,Tong Li
标识
DOI:10.1016/j.bbr.2024.114918
摘要
Depression has emerged as the predominant psychiatric affliction affecting individuals. Prior research has substantiated the antidepressant properties exhibited by numerous anesthetics. Sevoflurane, a widely utilized inhalant anesthetic in clinical practice, remains relatively uncharted in terms of its specific antidepressant effects. In this study, we used open field test, forced swimming test and novelty-suppressed feeding test to investigate the anxiety and depression-like behaviors in C57BL/6 mice following the inhalation of sevoflurane. We then used western blotting to scrutinized the expression levels of proteins associated with the brain-derived neurotrophic factor (BDNF)-tryosine receptor kinase B (TrkB) pathway in the hippocampus and prefrontal cortex. To further investigate whether sevoflurane exerts antidepressant-like effects via the BDNF-TrkB pathway, we downregulated TrkB expression by administering siRNA into the lateral ventricle. We found that the inhalation of 2.5% sevoflurane exerted a significant antidepressant-like effect, accompanied by an elevation in p-TrkB expression levels in the hippocampus and prefrontal cortex. Intriguingly, this antidepressant-like effect was abrogated following the downregulation of TrkB expression through the microinjection of siRNA into the lateral ventricle. In conclusion, this study provides evidence supporting the notion that sevoflurane exerts its antidepressant-like effect via the BDNF-TrkB signaling pathway.
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