抗菌肽
机制(生物学)
细胞内
抗菌剂
作用机理
计算生物学
生物
化学
行动方式
生物化学
微生物学
物理
量子力学
体外
作者
Shuqin Li,Yajie Wang,Zihan Xue,Yongxing Jia,Ruilin Li,Chengwei He,Hạixia Chen
标识
DOI:10.1016/j.tifs.2021.01.005
摘要
The rapid increase of drug resistance in conventional antibiotics promotes the discovery and development of antimicrobial peptides (AMPs), which are important components of natural immunity. Due to the specific action modes targeting for cell membrane, AMPs have become a promising substance for bacterium inhibitions barely with no drug resistance. Here we reviewed the structure characteristics related with bactericide actions, including peptides constituents, molecular length, molecular charges and so on. And we also summarized the common mode of actions of AMPs raised by researchers. The structure-mechanism relationship was discussed. The commonly used methods for mechanism study were also listed. The structures of AMPs were strongly related with its efficacy, such as constituents, molecular length, charges, secondary structures. The main mechanisms of AMPs were divided into membrane targets and intracellular targets. Some advanced and new techniques were applied in the mechanism study. Most of the existed mechanisms are still suppositional, and techniques were mainly focused on membrane-associated mechanism, only few of them were related with intracellular factors. Therefore, more new methods are expected to explore the authentic mechanisms and better results as well as more intracellular targets. This review provides a reference for future AMPs chemical modification and mechanism exploration.
科研通智能强力驱动
Strongly Powered by AbleSci AI