高尔基体
细胞生物学
功能(生物学)
囊泡转运蛋白
生物
分泌途径
膜
化学
生物化学
内质网
小泡
作者
Ilenia Agliarulo,Seetharaman Parashuraman
出处
期刊:Cells
[Multidisciplinary Digital Publishing Institute]
日期:2022-01-22
卷期号:11 (3): 368-368
被引量:21
标识
DOI:10.3390/cells11030368
摘要
Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp transition in membrane lipid composition by non-vesicular transport of lipids; and (c) vesicular sorting of proteins and lipids at the trans-Golgi network to target them to appropriate compartments. We discuss the molecules involved in these processes and their importance in physiology and development. We also discuss how mutations in these molecules affect plasma membrane composition and signaling leading to genetic diseases and cancer.
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