受体
细胞
生物物理学
DNA
细胞表面受体
细胞膜
细胞功能
功能(生物学)
纳米-
细胞生物学
纳米结构
化学
膜
纳米技术
材料科学
生物
生物化学
复合材料
作者
Kaixiang Zhang,Ruijie Deng,Yupeng Sun,Ling Zhang,Jinghong Li
出处
期刊:Chemical Science
[The Royal Society of Chemistry]
日期:2017-01-01
卷期号:8 (10): 7098-7105
被引量:63
摘要
Chemically functionalized and nanostructured materials, which mimic the features of the natural extracellular matrix, provide a tool to organize cell surface receptors into nanoscale clusters and manipulate cell functions. However, the existing materials are mainly based on static structures. Herein, we developed a DNA based structure-switchable and multivalent material that acts as a 'nano-spring', enabling reversible control of membrane receptor function at the cell surface. This 'nano-spring' can be easily synthesized by rolling circle amplification and finely tuned by changing the circular template design. Using this 'nano-spring' to interact with cells, we have demonstrated that the movement of the DNA nanostructure is sufficient to direct a cell morphology change from the normal morphology to having numerous cell protrusions and affect the mRNA expression level of integrin related genes. This DNA nano-spring structure can be a competitive material for actively manipulating cell receptor function and may help us to understand the role of receptor mediated signalling cascades.
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