鼻咽癌
生物
生物发生
环状RNA
癌症研究
基因
核糖核酸
计算生物学
细胞生物学
遗传学
医学
内科学
放射治疗
作者
Wanpeng Li,Rui Xu,Bijun Zhu,Huan Wang,Huankang Zhang,Li Hu,Xicai Sun,Hongmeng Yu,Dehui Wang
出处
期刊:Head & neck
[Wiley]
日期:2021-12-20
卷期号:44 (2): 494-504
被引量:3
摘要
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor of the nasopharyngeal mucosa with a high incidence rate in southern China and Southeast Asia and an evident ethnic and geographical distribution. Circular RNAs (circRNAs) are single-stranded noncoding RNAs with covalent, closed-loop structures. They are characterized by high stability and abundance, are evolutionarily conserved, and exhibit tissue/developmental stage specificity. Previous studies have shown that circRNAs are associated with the occurrence and development of various malignant tumors. However, the expression patterns and clinical significance of circRNAs in NPC remain ambiguous. Hence, the present review focuses on the biogenesis and regulation of circRNAs, and the functional roles of abnormally expressed circRNAs in NPC. In addition, the current review discusses the possibility of utilizing circRNAs as potential clinical biomarkers for the diagnosis and prognosis of NPC.
科研通智能强力驱动
Strongly Powered by AbleSci AI