医学
随机对照试验
尿失禁
富血小板血浆
尿
泌尿系统
泌尿科
不利影响
压力性尿失禁
下尿路症状
物理疗法
内科学
血小板
前列腺
癌症
作者
Themos Grigoriadis,Christos Kalantzis,Dimitrios Zacharakis,Nikolaos Kathopoulis,Anastasia Prodromidou,Sofia Xadzilia,Stavros Athanasiou
标识
DOI:10.1097/spv.0000000000001378
摘要
Urinary incontinence affects millions of women worldwide.The aim of the current study was to evaluate the efficacy and safety of periurethral platelet-rich plasma (PRP) injections in women with stress urinary incontinence (SUI).This was a single-center, double-blind, randomized sham-controlled trial. Fifty participants with SUI and urodynamic stress incontinence were randomized in 2 equally sized groups. Women in the PRP group received 2 PRP injections at 3 levels of the urethra at 4- to 6-week intervals. Women in the sham group were injected with sodium chloride 0.9%. At baseline, participants underwent urodynamic studies and a 1-hour pad test and completed the International Consultation on Incontinence Questionnaire-Female Lower Urinary Tract Symptoms (ICIQ-FLUTS), the Patient Global Impression Scale of Improvement, and the King's Health Questionnaire. At follow-up visits (1, 3, and 6 months), women underwent the 1-hour pad test and completed the King's Health Questionnaire and the ICIQ-FLUTS. Primary outcome was the subjective evaluation as indicated by the response to question 11a of the ICIQ-FLUTS questionnaire. Secondary outcomes included scores of questionnaires and urine loss assessed on the 1-hour pad test. The level of discomfort during injections and any adverse events were also evaluated.During follow-up, the mean score of the 11a question decreased significantly in the PRP group compared with sham. Subjective cure was significantly higher in the PRP group (32% vs 4%, P < 0.001). A significant reduction of urine loss assessed on the 1-hour pad test was observed in the PRP group compared with the sham group at 6-month follow-up. No adverse events were observed.Periurethral PRP injections were superior to sham injections in improving SUI symptoms with an excellent safety profile.
科研通智能强力驱动
Strongly Powered by AbleSci AI