Signal transducers and activators of transcription 3 signaling pathway in the pathogenesis and treatment of psoriasis

Signal transducer and activator of transcription 3(STAT3),as an important nuclear transcription factor,can inhibit cell apoptosis,promote cell proliferation and participate in such cell biological processes as survival,transformation and migration.STAT3 plays an important role in skin diseases with the characteristics of over proliferation and abnormal differentiation of the epidermis,such as psoriasis.STAT3 is an important signal transducer and transcription activator in the pathogenesis of psoriasis.Blocking the signaling pathway of STAT3 could become a novel and effective method for the treatment of psoriasis.