The extraction performance and mechanism of Fe(Ⅲ) with N,N,N',N'-tetrabutyl-3-oxy-glutaramide were studied in two diluents.The influence of the concentration of hydrochloric acid,TBOPDA and the temperature on the extraction had been investigated.The results showed that the extraction distribution ratio of Fe(Ⅲ) increased with the increase of the concentration of hydrochloric acid.Extraction distribution increased with the increase of extractant concentration.The distribution ratio decreased with the increase of temperature,and the extraction reaction was exothermic.