Study on the relationship of adiponectin,TNF-α with type 2 diabetes mellitus retinopathy

Objective To study the pathogenesis in type 2 diabetes(DM) retinopathy(DR)about adiponectin and tumor necrosis factor(TNF-α).Method Adiponectin and TNF-α were measured in the serum of 90 cases of type 2 diabetes patients and 40 healthy human by enzyme-linked immunosorbent assay(ELISA).The 90 patients were divided into non-DR(NDR) group,background-DR group(BDR) and proliferative-DR(PDR) grioup.Result ①The serum adiponectin and TNF-α levels in DM group were lower than in the control group(P0.05);② The levels of adiponectin and TNF-α in BDR group were less than in NDR group(P0.05);③The contents of adiponectin and TNF-α in PDR group were less than NDR group's(P0.01);④The contents of adiponectin and TNF-α in PDR group were less than BDR group(P0.05);⑤The gravity of DR were negatively correlated to the levels of adiponectin(r=-0.428,P0.01).Conclusion The reduction of adiponectin and TNF-α plays an important role in the pathogenesis of DM.The adiponectin and TNF-α may be involved in the occurrence and development of DR because the levels of blood adiponectin and TNF-α are more lower in type 2 diabetic retinopathy.