神经毒性
锰
多巴胺能
生物标志物
遗传倾向
毒性
神经科学
化学
多巴胺
医学
生物
内科学
疾病
生物化学
有机化学
摘要
Long-term occupational exposure to manganese might cause manganese poisoning, which would had adverse effects on nervous system of workers. The basal nucleus was damaged and dopaminergic neuron was injuried by manganese. The mechanism could be related with interfering the energy metabolism of central nerve, changing neurotransmitters, activating oxidation system and so on. Genetic factors may also plays a significant role in the neurotoxicity caused by manganese. Study the effects of manganese exposure biomarker, the neurotoxicity of biomarkers and the genetic susceptibility to early and susceptibility biomarkers will contribute to the prevention and control of manganese neurotoxicity.
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