化学
双环分子
位阻效应
酰亚胺
加合物
立体化学
戒指(化学)
药物化学
有机化学
作者
P. Ashkenazi,David Ginsburg,G. Scharf,Benzion Fuchs
出处
期刊:Tetrahedron
[Elsevier]
日期:1977-01-01
卷期号:33 (11): 1345-1348
被引量:10
标识
DOI:10.1016/0040-4020(77)84083-0
摘要
Reaction of 1,2-dihydrophthalic anhydride and several of its imide derivatives, 1,2-dihydrophthalide and 1,2-dihydrophthalan with N-methyl- and N-phenyl-1,2,4-triazoline-3,5-dione affords two configurational families of adducts through attack from both possible directions. Major attack in the first three cases occurs mainly syn- to the hetero-ring but in the two latter cases anti- to it. These results may be explained by invoking stabilization of the transition state in the former cases through secondary orbital overlap and by simple steric effects in the latter.
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