Optimizing Dose Per Fraction: A New Chapter in the Story of the Abscopal Effect?

I had the privilege to be mentored by Rodney Withers and Jack Fowler, two of the many scientific giants who dedicated their lives to the subject of radiation dose and fractionation (D&F). I also always remember Norman Coleman's sentence that “Radiation is a different drug at different doses and fractionation schedules.” It is not then a surprise that when we ventured into exploring the immune effects of radiation therapy, I encouraged the laboratory to focus on investigating the optimal D&F.