免疫疗法
癌症研究
免疫系统
肿瘤微环境
CD8型
趋化因子
运输机
肝细胞癌
细胞毒性T细胞
CXCL10型
癌症免疫疗法
T细胞
生物
免疫学
生物化学
基因
体外
作者
Yuan Fang,Weiren Liu,Zheng Tang,Xiang Ji,Yufu Zhou,Shushu Song,Meng‐Xin Tian,Chenyang Tao,Run Huang,Guiqi Zhu,Xi‐Fei Jiang,Jun Gao,Wei‐Feng Qu,Han Wang,Pei‐Yun Zhou,Xiaoling Wu,Jin Lei,Haixiang Sun,Zhen‐Bin Ding,Yuan‐Fei Peng
出处
期刊：Hepatology
[Lippincott Williams & Wilkins]
日期：2022-01-19
卷期号：77 (1): 109-123
被引量：138
摘要
Our results revealed that lactate exportation by MCT4 has a tumor-intrinsic function in generating an immunosuppressive HCC environment and demonstrated the proof of the concept of targeting MCT4 in tailoring HCC immunotherapeutic approaches.
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