牙周炎
CCR2型
医学
牙槽
炎症
破骨细胞
骨吸收
二、侵袭性牙周炎
牙龈卟啉单胞菌
CD64
免疫学
病理
内科学
流式细胞术
趋化因子
牙科
趋化因子受体
受体
作者
Wangjie Jiang,Tao Xu,Shasha Yuan,Yiping Wei,Zhanming Song,Qingqing Li,Shaoping She,Xuekang Wang,Cui Wang,Gang Yang,Jie Cao,Fei Sun,M. Shi,Siqi Li,Zhongtian Liu,Yaqian Mo,Ping Lv,Yu Zhang,Ying Wang,Wenjie Hu
摘要
Abstract Aim CCR2 plays important roles in many inflammatory and bone metabolic diseases, but its specific role in periodontitis is unknown. In the present study, we aimed to explore the role of CCR2 in the progression of periodontitis and evaluate the effect of cenicriviroc (CVC) on periodontitis. Materials and Methods The expression of CCR2 was studied in patients with periodontitis and in ligation‐induced murine model of periodontitis. The role of CCR2 in promoting inflammation and bone resorption in periodontitis was evaluated in Ccr2 −/− mice and wild‐type mice. The effect of CVC in the prevention and treatment of periodontitis was evaluated by systemic and local medication. Microcomputed tomography, haematoxylin and eosin staining, tartrate‐resistant acid phosphatase staining, quantitative real‐time polymerase chain reaction, enzyme‐linked immunosorbent assay, and flow cytometry were used for histomorphology, molecular biology, and cytology analysis, respectively. Results In this study, we demonstrated that CCR2 was highly expressed in human and murine periodontitis and that CCR2 deficiency was associated with decreased inflammatory monocyte and macrophage infiltration and inflammatory mediators, osteoclast number and alveolar bone resorption. Prevention and treatment with CVC significantly reduced the severity of periodontitis, regardless of whether it was administered systemically or locally. Conclusions CCR2 plays an important role in the development and progression of periodontitis, and CVC is a potential drug for the prevention and treatment of periodontitis.
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