Design, synthesis via a one-pot approach and molecular docking studies of novel pyrrolo[2,1-a]isoquinoline derivatives

This new investigation describes an efficient three-component approach for the stereoselective synthesis of pyrrolo[2,1- a ]isoquinolines from readily available isatins, chalcones and 1,2,3,4-tetrahydroisoquinoline without using any metal catalyst or additive.