干细胞
调节器
肠上皮
缺氧(环境)
细胞生物学
癌症研究
生物
免疫学
化学
医学
上皮
病理
生物化学
基因
有机化学
氧气
作者
Penglin Xia,Yong Yang,Ruling Liu,Zhenlan Feng,Yuhan Lin,Huiqin Tang,Jicong Du,Ying Cheng,Jianming Cai,Hao Hu,Cong Liu,Xiaotian Xu,Liu Hu
标识
DOI:10.1016/j.toxlet.2021.12.011
摘要
Damage of Intestinal Stem Cells (ISCs) is the main cause of radiation induced-intestinal injury (RIII). Recently, hypoxia Inducible factor (HIF) was verified to be critical for promoting proliferation of ISCs, which suggested a protective role of HIF in the RIII. Thus, we investigated the effect of FG-4592, a novel up-regulator of HIF, on the protection of RIII. With/without FG-4592 treatment, the abdomen of mice was radiated, and intestinal injury was assessed. Especially, by intestinal organoid culture, the multiplication capacity and differentiation features of ISCs were detected. As a result, FG-4592, a novel up-regulator of HIF could remit RIII and promote regeneration and differentiation of ISCs after radiation, which were depended on HIF-2 rather than HIF-1.
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