Bifunctional Chiral Organocatalysts in Organic Transformations

In continuation to our earlier review, we report herein further development on the organocatalytic approach for the synthesis of enantioenriched organic compounds. Application of synthetic bifunctional chiral organocatalysts with emphasis on Brønsted acid catalyst derived from chiral phosphoric acid derivative, and mechanism of asymmetric catalysis are discussed. Keywords: Asymmetric organocatalysis, axially chiral binaphthyl, Bronsted acid catalyst, chiral thiourea, absolute configuration, synthesis