非酒精性脂肪肝
失调
梯形物种
微生物群
毛螺菌科
肠道菌群
细菌
梭杆菌门
疾病
医学
生物
脂肪肝
生物信息学
生态学
内科学
免疫学
生态系统
遗传学
厚壁菌
16S核糖体RNA
作者
Dingfeng Wu,Lei Liu,Na Jiao,Yida Zhang,Li Yang,Chuan Tian,Ping Lan,Lixin Zhu,Rohit Loomba,Rong Zhu
出处
期刊:iMeta
[Wiley]
日期:2022-11-16
卷期号:1 (4)
被引量:11
摘要
Abstract The dysbiosis of the gut microbiome is one of the pathogenic factors of nonalcoholic fatty liver disease (NAFLD) and also affects the treatment and intervention of NAFLD. Among gut microbiomes, keystone species that regulate the integrity and stability of an ecological community have become the potential intervention targets for NAFLD. Here, we collected stool samples from 22 patients with nonalcoholic steatohepatitis (NASH), 25 obese patients, and 16 healthy individuals from New York for 16S rRNA gene sequencing. An algorithm was implemented to identify keystone species based on causal inference theories and dynamic intervention simulation. External validation was performed in an independent cohort from California. Eight keystone species in the gut of NAFLD, represented by Porphyromonas loveana, Alistipes indistinctus , and Dialister pneumosintes , were identified, which could efficiently restore the microbial composition of the NAFLD toward a normal gut microbiome with 92.3% recovery. These keystone species regulate intestinal amino acid metabolism and acid–base environment to promote the growth of the butyrate‐producing Lachnospiraceae and Ruminococcaceae species that are significantly reduced in NAFLD patients. Our findings demonstrate the importance of keystone species in restoring the microbial composition toward a normal gut microbiome, suggesting a novel potential microbial treatment for NAFLD.
科研通智能强力驱动
Strongly Powered by AbleSci AI