生物
转录因子
癌变
肾细胞癌
计算生物学
癌症研究
细胞生物学
遗传学
癌症
基因
病理
医学
作者
Yuanyuan Qu,Xiaohui Wu,Aihetaimujiang Anwaier,Jinwen Feng,Wenhao Xu,Xiaoru Pei,Yu Zhu,Yang Liu,Lin Bai,Guang Yang,Xi Tian,Jiaqi Su,Guohai Shi,Dalong Cao,Fujiang Xu,Yue Wang,Hualei Gan,Shujuan Ni,Menghong Sun,Jian Zhao,Hailiang Zhang,Dingwei Ye,Ding Chen
标识
DOI:10.1038/s41467-022-34460-w
摘要
Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is a rare type of kidney cancer, which is not well characterized. Here we show the comprehensive proteogenomic analysis of tRCC tumors and normal adjacent tissues to elucidate the molecular landscape of this disease. Our study reveals that defective DNA repair plays an important role in tRCC carcinogenesis and progression. Metabolic processes are markedly dysregulated at both the mRNA and protein levels. Proteomic and phosphoproteome data identify mTOR signaling pathway as a potential therapeutic target. Moreover, molecular subtyping and immune infiltration analysis characterize the inter-tumoral heterogeneity of tRCC. Multi-omic integration reveals the dysregulation of cellular processes affected by genomic alterations, including oxidative phosphorylation, autophagy, transcription factor activity, and proteasome function. This study represents a comprehensive proteogenomic analysis of tRCC, providing valuable insights into its biological mechanisms, disease diagnosis, and prognostication.
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