雷公藤
圆二色性
化学
立体化学
衍生工具(金融)
化学结构
有机化学
医学
替代医学
病理
金融经济学
经济
作者
Ya-Lin Hu,Bo Hu,Tianqi Xu,Hongyu Li,Huai-Yu Cheng,Xia Zhang,Wei Xu,Chun-Lin Fan,Guang‐Xiong Zhou
标识
DOI:10.1080/10286020.2022.2164490
摘要
A chemical investigation of 95% ethanol extract from the stem and branch of Tripterygium wilfordii has resulted in the isolation and characterization of two new compounds, one neolignan (1) and one phenylalanine derivative (2), as well as four known compounds (3–6). The structures of the new compounds were determined based on extensive spectroscopic analyses. The absolute configuration of compound 1 was defined by X-ray crystallographic analyses and electronic circular dichroism calculation. In addition, compounds 2 and 4–6 exhibited inhibitory effects against NO production in LPS-induced RAW 264.7 macrophages with the IC50 value ranging from 3.51 μM to 30.40 μM.
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