氧化应激
颞叶皮质
昼夜节律
神经科学
痴呆
皮质(解剖学)
睡眠剥夺对认知功能的影响
内分泌学
内科学
脂质过氧化
氧化磷酸化
心理学
抗氧化剂
认知
化学
医学
生物化学
疾病
作者
Cinthia Coria-Lucero,Andrea Castro,Carina Ledezma,Jorge Leporatti,Darío C. Ramírez,Marisa Ghersi,Silvia Marcela Delgado,Ana Cecilia Anzulovich,Lorena Navigatore-Fonzo
标识
DOI:10.1016/j.brainres.2023.148242
摘要
Alzheimer's dementia (AD) is a neurodegenerative disorder that causes memory loss and dementia in older adults. Intracellular accumulation of Aβ causes an imbalance in the oxidative status and cognitive dysfunctions. Besides oxidative stress and loss of memory, Alzheimer's patients show dysfunction of the circadian rhythms. The objective of this work was to evaluate the consequences of an intracerebroventricular injection of Aβ (1–42) on temporal patterns of cognitive performance, as well as on lipid peroxidation, protein oxidation and total antioxidant capacity levels, in the rat temporal cortex. Holtzman male rats from control and Aβ-injected groups were used in this study. We found that MDA, protein carbonyls and total antioxidant capacity levels displayed day-night oscillations in the rat temporal cortex and spatial memory performance also varied rhythmically. An intracerebroventricular injection of Aβ (1–42) modified temporal patterns of cognitive performance as well as daily profiles of parameters of oxidative stress. Thus, elevated levels of Aβ aggregates induces alterations in daily rhythmicity of parameters of oxidative stress and, consequently, would affect cellular clock activity, affecting the spatial memory performance in the AD.
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