化学
三氟乙酸酐
异喹啉
小檗碱
废止
三氟乙酸
全合成
有机化学
醋酸酐
自由基
盐酸小檗碱
组合化学
催化作用
盐(化学)
作者
Xifei Yan,Jianfeng Zheng,Wei‐Dong Z. Li
标识
DOI:10.1016/j.tetlet.2023.154826
摘要
The total syntheses of berberine hydrochloride and its analogues were achieved by a convergent strategy from available meconine derivatives, which were based on base mediated isoquinoline annulation followed by trifluoroacetic anhydride promoted decarbonylative elimination protocol. Key elements of our approach feature divergent synthesis, step-economy manner, multigram scalable synthesis, transition metal-free and chromatography-free purification.
科研通智能强力驱动
Strongly Powered by AbleSci AI