急性呼吸窘迫综合征
医学
急性呼吸窘迫
脂多糖
肺
重症监护医学
炎症
弥漫性肺泡损伤
肺水肿
药品
免疫学
药理学
内科学
作者
Hong Chen,Chunxue Bai,Xiangdong Wang
摘要
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a syndrome characterized by pulmonary edema and acute inflammation. Lipopolysaccharide (LPS), a major component in Gram-negative bacteria, has been used to induce ALI/ARDS. LPS-induced animal models highlight ways to explore mechanisms of multiple diseases and provide useful information on the discovery of novel biomarkers and drug targets. However, each model has its own merits and drawbacks. The goal of this article is to summarize and evaluate the results of experimental findings in LPS-induced ALI/ARDS, and the possible mechanisms and treatments elucidated. Advantages and disadvantages of such models in pulmonary research and new directions for future investigations are also discussed.
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