托珠单抗
免疫学
炎症
自身免疫
背景(考古学)
生物
关节炎
类风湿性关节炎
免疫
免疫系统
发病机制
疾病
医学
内科学
古生物学
作者
Toshio Tanaka,Masashi Narazaki,Tadamitsu Kishimoto
出处
期刊:Cold Spring Harbor Perspectives in Biology
[Cold Spring Harbor Laboratory]
日期:2014-09-04
卷期号:6 (10): a016295-a016295
被引量:2858
标识
DOI:10.1101/cshperspect.a016295
摘要
Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. Although its expression is strictly controlled by transcriptional and posttranscriptional mechanisms, dysregulated continual synthesis of IL-6 plays a pathological effect on chronic inflammation and autoimmunity. For this reason, tocilizumab, a humanized anti-IL-6 receptor antibody was developed. Various clinical trials have since shown the exceptional efficacy of tocilizumab, which resulted in its approval for the treatment of rheumatoid arthritis and juvenile idiopathic arthritis. Moreover, tocilizumab is expected to be effective for other intractable immune-mediated diseases. In this context, the mechanism for the continual synthesis of IL-6 needs to be elucidated to facilitate the development of more specific therapeutic approaches and analysis of the pathogenesis of specific diseases.
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