内科学
内分泌学
内分泌系统
脂质代谢
激素
生物
雌激素
斑马鱼
下丘脑-垂体-性腺轴
氯硝柳胺
医学
生物化学
生态学
基因
促黄体激素
作者
Xianglin Chen,Shangyue Yang,Biran Zhu,Mengyuan Zhang,Na Zheng,Jianghuan Hua,Ruiwen Li,Jian Han,Lihua Yang,Bingsheng Zhou
标识
DOI:10.1016/j.scitotenv.2023.168737
摘要
Niclosamide (NIC) is a commonly used molluscicide that reportedly disrupts the endocrine system and may lead to lipid metabolism disorders. However, few studies have investigated the mechanism by which NIC affects the endocrine system from the perspective of lipid metabolism. Adult female zebrafish were fed either a normal-fat diet (NFD) or a high-fat diet (HFD) and then exposed for 28 days to environmentally relevant concentrations of NIC. NIC accumulated most in the liver followed by the brain and then the gonads in both feeding conditions. Somatic index changes confirmed that HFD promotes fish growth, and NIC administration inhibits it. Lipid metabolites were decreased by NIC, as were levels of pregnenolone, androstenedione, estrogen, testosterone, and estradiol, suggesting that NIC impacted steroidogenesis. In addition, gene transcription changes related to the hypothalamic-pituitary-gonad-liver (HPGL) axis and altered ovarian histology strongly suggest that environmental relevant concentrations of NIC exposure may disrupt endocrine function. These findings highlighted that NIC exposure at environmentally relevant concentrations elicited endocrine-disruption effects may through impairing of steroid hormone synthesis.
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