A map of mitochondrial biology reveals the energy landscape of the human brain

Mapping the density, molecular features and energy-transformation capacity of cell organelles called mitochondria in the brain reveals region- and cell-type-specific variability that tracks with evolutionary patterns. Correlations between mitochondrial and brain-imaging metrics could enable future non-invasive explorations of mitochondrial bioenergetics in the brain in health and disease. A computational model can predict bioenergetics across the brain using standard neuroimaging data.