化学
苯并咪唑
抗氧化剂
部分
DPPH
弹性蛋白酶
有机化学
席夫碱
组合化学
核化学
立体化学
酶
作者
Canan Albay,Gülhan Tekbaş
摘要
Starting from the 5,6-dichloro-2-phenyl-1H-benzimidazole, new benzimidazole derivatives having schiff base, carbothioamide, thiadiazole, and triazole moiety were synthesized and characterized. Synthesized compounds were characterized by NMR spectroscopy, mass spectroscopy and elemental analyses techniques. Antioxidant and elastase inhibitory activities of compounds were also investigated. The inhibitory effects on elastase activity of the synthesized molecules were analyzed spectrophotometrically. The antioxidant activities of molecules were investigated by both methods as DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging activity and iron reducing power capacities. All synthesized compounds showed good antioxidant and elastase inhibitory activity. Compound 2 showed the highest elastase inhibition. Compound 3 and compound 2 showed the highest antioxidant activity by DPPH method, and iron reducing power method, respectively.
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